Figure 6.

Effect of α-syn expression on neurotransmitter content in brain of old-aged untreated (gene on) and treated (gene off) conditional mice. A–C, Content of neurotransmitter was measured in the olfactory bulb (A), striatum (B), and the midbrain region (including the substantia nigra; C). Untreated (gene on) CaM_α-syn mice (males, n = 1; females, n = 5) and controls (males, n = 2; females, n = 6), treated (gene off) CaM_α-syn mice (males, n = 2; females, n = 2) and equally treated controls (males, n = 3; females, n = 2) were used for HPLC analysis. CaM_α-syn mice showing significant reduction of DA in the olfactory bulb, which was reserved by treatment with dox. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, compared with corresponding group.