Table 1.
Comparison of SPN properties in control conditions and in the presence of SCH-23390, sulpiride, or d-AP-5
| Control (n = 74) | SCH-23390 (n = 16) | Sulpiride (n = 14) | d-AP-5 (n = 12) | |
|---|---|---|---|---|
| RMP (mV) | −83.5 ± 0.4 | −83.4 ± 1.3 | −82.4 ± 0.7 | −85.4 ± 0.7 |
| Input resistance (MΩ) | 139 ± 10 | 137 ± 9 | 164 ± 22 | 138 ± 15 |
| AP amplitude (mV) | 74.8 ± 1.3 | 76.8 ± 2.5 | 74.5 ± 2.7 | 77.3 ± 3.0 |
| AP threshold (mV) | −33.9 ± 0.8 | −35.5 ± 1.4 | −33.3 ± 2.0 | −35.9 ± 1.8 |
| AP half-width (ms) | 1.04 ± 0.02 | 1.05 ± 0.03 | 1.06 ± 0.11 | 1.12 ± 0.04 |
| AP delay (ms) | 147 ± 5 | 155 ± 8 | 136 ± 8 | 138 ± 11 |
| AHP amplitude (mV) | −12.0 ± 0.3 | −10.4 ± 0.8 | −12.4 ± 0.8 | −10.5 ± 0.6 |
| AHP time to peak (ms) | 14.5 ± 1.1 | 13.7 ± 1.8 | 12.8 ± 2.1 | 14.5 ± 1.5 |
| I inj. threshold to elicit AP (pA) | 265 ± 16 | 240 ± 26 | 250 ± 23 | 266 ± 31 |
| # APs at threshold | 1.2 ± 0.1 | 1.3 ± 0.1 | 1.2 ± 0.1 | 1.2 ± 0.1 |
| # APs 50 pA above threshold | 3.1 ± 0.2 | 3.3 ± 0.3 | 2.9 ± 0.8 | 3.0 ± 0.3 |
| EPSP amplitude (mV) | 4.80 ± 0.29 | 4.68 ± 0.60 | 4.02 ± 0.29 | 4.09 ± 0.56 |
| EPSP 20–80% RT (ms) | 2.10 ± 0.13 | 2.33 ± 0.12 | 2.51 ± 0.23 | 2.39 ± 0.17 |
| EPSP latency (ms) | 2.58 ± 0.10 | 2.10 ± 0.17 | 2.93 ± 0.18 | 2.71 ± 0.15 |
| EPSP half-width (ms) | 15.3 ± 0.7 | 18.5 ± 1.0* | 19.3 ± 1.6* | 14.8 ± 0.4 |
| PPR | 1.27 ± 0.07 | 1.06 ± 0.12 | 0.91 ± 0.08* | 1.15 ± 0.12 |
Data are mean ± SEM (*p < 0.05). Time-to-peak and amplitude of afterhyperpolarization (AHP) were measured from AP threshold. I inj., Current injection required to elicit APs; #, number of obtained APs; RT, rise time. AP delay was determined with respect to onset of current injection.