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. 2008 Mar 5;28(10):2624–2632. doi: 10.1523/JNEUROSCI.5245-07.2008

Figure 6.

Figure 6.

Effect of p25/cdk5 activation on GSK3β regulation and tau phosphorylation in adult mice. A, Representative blots and statistical analysis showing GSK3β, GSK3β–S9, and ErbB signaling components including pAktS473, total Akt, pPI3KY199, pErbB2Y877, and p35/p25 in Ntg (n = 5) and p25 (n = 6) mice at 3 months of age. B, Representative blots showing phospho-tau at sites pS396/pS404 (PHF-1), pS199, dephosphorylated tau (Tau1), total tau, and actin levels (loading control). Although there was a trend to decrease for S199, overall levels of tau phosphorylation level indicated by Tau1 showed no change at this age. C, Comparison between the GSK3β–S9 levels for 5-d-old and 3-month-old mice (3 mice each shown). Inhibitory phosphorylation at the S9 site was significantly reduced in 3-month-old mice.