Figure 8.
Effect of cdk5 inhibitor CP-681301 on GSK3β regulation, tau phosphorylation, and Aβ production in vivo in aged mice. A, Representative blots showing the effect of CP-681301 treatment on GSK3β, GSK3β–S9, dephosphorylated tau (Tau1), phosphorylated tau at sites pS199 and pS235, and actin in Ntg mice treated with vehicle (Veh; n = 6) or with CP-681301 (CP; n = 6). B, Analysis of soluble Aβ1–40 and Aβ1–42 levels in Ntg mice treated with vehicle or with cdk5 inhibitor CP-681301. Mice used in this study were between 24 and 28 months of age.