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. 2008 Jan 30;28(5):1099–1108. doi: 10.1523/JNEUROSCI.4906-07.2008

Figure 3.

Figure 3.

UNC5 expression in spinal cord. a, b, f, g, l, m, Coronal sections through adult intact cervical spinal cord (darkfield). c, d, h, i, n, o, Coronal sections through adult thoracic spinal cord (T6) after a sham lesion (c, h, n) and 2 weeks after a T7 full transection lesion (d, i, o). Expression of the netrin-receptors UNC5A (c, d), UNC5C (h, i) and DCC (n, o) is restricted to the spinal cord gray matter, and expression patterns are maintained 2 weeks after spinal cord transection. Compared with sham-lesioned animals, levels of UNC5A (e), UNC5C (k) and DCC (p) by real-time PCR are reduced to 42.8 ± 9.3% (SEM), 58.5 ± 8.6% (SEM) and 80.3 ± 0.85% (SEM) in the adjacent rostral spinal cord and to 29.8 ± 5.9% (SEM), 44.8 ± 6.3% (SEM) and 65.8 ± 5.7% (SEM) in the adjacent caudal spinal cord segments, respectively, 4 weeks after T7 complete transection (ANOVA, *p < 0.05, **p < 0.01, ***p < 0.001).