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. 2008 Jan 30;28(5):1046–1057. doi: 10.1523/JNEUROSCI.4497-07.2008

Figure 2.

Figure 2.

Contribution of TRPV4 to neuropathic mechanical hyperalgesia. A, Rats were treated with either TRPV4 antisense (AS) or mismatch (MM) ODN for 6 d. Streptozotocin was administered on day 3. Two-way repeated-measures ANOVA showed a significant group by time interaction (F (4,88) = 22.511; p < 0.001) and a significant main effect of group (F (1,22) = 34.107; p < 0.001). Post hoc one-way ANOVAs (group with 2 levels, antisense and mismatch) revealed that paw withdrawal threshold differed significantly between the two groups from day 4 (the first day after receiving STZ) to day 8. B, TRPV4 antisense or mismatch ODN were administered daily for 14 d starting 3 d before the commencement of ethanol diet. Rats were fed the ethanol diet for four days of the week [day 0 (D0)–D4], and they were fed standard lab chow for the remaining three days (D4–D7). A repeated-measures ANOVA with one within-subjects factor (days with 10 levels) and one between-subjects factor (ODN with 2 levels, antisense and mismatch) demonstrated a significant ODN by days interaction (F (9,90) = 18.448; p < 0.001) and a significant main effect of ODN (F (1,10) = 50.744; p < 0.0001). Post hoc one-way between-subjects ANOVAs showed that the ODN groups differed significantly from day 7 (p < 0.001) to day 15 (p = 0.051).