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. 2008 Jan 30;28(5):1064–1075. doi: 10.1523/JNEUROSCI.1565-06.2008

Figure 5.

Figure 5.

WIN and AM1241 desensitize ICAP and IMO in TRPV1- and/or TRPA1-expressing CHO cells. A, WIN (25 μm), ACEA (25 μm), and AM1241 (30 μm) as well as CAP (0.3 μm) inhibit ICAP (0.3 μm) in TRPV1/TRPA1-expressing CHO cells. B, TRPV1-gating ACEA, but not TRPA1-gating WIN and AM1241 attenuates ICAP (0.3 μm) in TRPV1-expressing CHO cells. C, ACEA and WIN (25 μm each), as well as MO (50 μm), inhibit IMO (50 μm) in TRPA1–TRPV1-expressing CHO cells, whereas only TRPA1-gating agonists WIN and MO still show inhibition of IMO in TRPA1-expressing CHO cells. CHO cells were treated 2 min with MO, ACEA, WIN, and AM1241, and 30 s with CAP. ICAP were recorded by CAP application during 40 s, whereas MO was applied for 2 min to record IMO. The interval between treatment and IMO or ICAP registration was 3 min. The numbers of responsive CHO cells are shown inside the bars. Error bars are SEM. *p < 0.05; **p < 0.01.