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. 2008 Jan 30;28(5):1064–1075. doi: 10.1523/JNEUROSCI.1565-06.2008

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Copyright © 2008 Society for Neuroscience 0270-6474/08/281064-12$15.00/0

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Figure 7. — The TRPA1 channel mediates WIN- and AM1241-induced inhibitions of I_CAP in TG neurons. A, Oblation of TRPA1 function with ALab-siRNA, but not mock and ADr-siRNA, transfections reversed inhibitory effects of WIN (25 μm) and AM1241 (30 μm), but not CAP (0.3 μm), on I_CAP (0.3 μm) in TG neurons. TG neurons were treated 2 min with WIN and AM1241, and 30 s with CAP. I_CAP were generated by 40 s application of CAP. Interval between treatments and I_CAP recording was 3 min. The numbers of analyzed TG neurons are shown inside the bars. One round of siRNA transfection was used. TG neurons were cultured for 3 d. B–D, I_WIN, I_AM1241, and I_CAP traces recorded during experiments on mock (C), ADr (D), and ALab (E) siRNA-transfected TG neurons. Durations of particular drug applications are marked with horizontal bars.