Skip to main content
. 2019 Aug 1;12(4):488–493. doi: 10.1093/ckj/sfz103

FIGURE 3.

FIGURE 3

Non-muscle myosin heavy chain IIA structure and sites of mutations. The MYH9 gene encodes the heavy chain of non-muscle myosin IIA. (A) Primary structure of the heavy chain of non-muscle myosin IIA. Some of the most frequent mutations are indicated. In Italy, 68% of families carried mutations leading to changes in amino acids 702 (motor domain) or 1424, 1841 and 1933 (tail domain). Motor domain mutations and D1424H are associated with the highest risk of kidney disease [2]. Some mutations are colour-coded in traffic light style as per the risk of kidney disease, red being the highest. (B) Quaternary structure of non-muscle myosin IIA: it is a hexamer composed two heavy chains, two regulatory light chains, whose phosphorylation regulates protein function, and two essential light chains. Key phosphorylation sites on the heavy chain are indicated.