Figure 5.

vMIP-2, a broad-spectrum chemokine receptor antagonist, prevents microglial recruitment in the CA1 region after TFI. A, Fluorescent photomicrographs of CA1 sections labeled with an OX-42 antibody after sham operation (Ctrl), 3 d after forebrain ischemia alone (FI), or with an intracerebroventricular injection of 1 μg of vMIP-2 or MC148. Scale bar, 200 μm. B, The number of OX-42-immunopositive (ip) microglial cells at 3 d after FI with an intracerebroventricular injection of 1 μg of vMIP-2 at 0, 12, and 24 h after reperfusion was analyzed and presented as means ± SEM (n = 4 animals for each condition). *Significantly different from the relevant control at p < 0.05 using ANOVA and Student–Newman–Keuls analyses.