Table 2.

Ontogeny of E_GABA changes in male and female rat CA1 pyramidal neurons

Groups	n	EGABA(mean ± SEM; mV)	p	EGABA − Vr (mean ± SEM; mV)	p
Male P4–P7	7	−58.7 ± 3		8.3 ± 2.8
Male P8–P13	7	−62.4 ± 3.1		5.6 ± 3
Male P14–P18	8	−74.2 ± 2.9	< 0.05**	−3.3 ± 2.8	< 0.05**
Female P4–P7	12	−68 ± 2.4	< 0.05*	−3 ± 2.4	< 0.05*
Female P8–P13	17	−71.3 ± 2	< 0.05*	−2.5 ± 1.2	< 0.05*
Female P14–P18	6	−81.2 ± 3.3	< 0.05**	−10.6 ± 3.2	< 0.05**

E_GABA and E_GABA − V_r were determined in P4–P18 male and female CA1 pyramidal neurons from CON rats, using gramicidin-perforated patch clamp. Significant sex- and age-related differences were observed.

*Significant difference versus same age male group; **significant difference versus either of the P4–P7 or P8–P13 same-sex groups.