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. 2008 Feb 13;28(7):1773–1785. doi: 10.1523/JNEUROSCI.3916-07.2008

Figure 4.

Figure 4.

Perturbations of single-cell oscillatory bursting activity by attenuation of NaP. A, Example of current-clamp recording of pre-BötC oscillatory bursting neuron (isolated from excitatory synaptic input by bath-applied 20 μm CNQX). Bath-applied riluzole (10 μm) progressively slows and stops neuron oscillatory bursting, but does not block action potential generation (right bottom trace) during sustained current injection. B, C, Time course of reduction in burst frequency and NaP amplitude (measured at −40 mV from voltage-clamp ramp I–V curve) for a group of intrinsic oscillatory burster neurons by bath-applied riluzole (B; n = 12) or low concentration of TTX (C; 20 nm; n = 12). Neurons stop endogenous bursting after ∼70–80% reduction in NaP amplitude. Complete block of NaP occurs within 3 min; gLeak is unaffected by riluzole or TTX.