Figure 6.

Perturbations of network oscillations by low concentrations of TTX. A, B, Bath application of low concentrations of TTX (A) (n = 10), or continuous bilateral microinfusion (n = 12 slices) of low concentrations of TTX into the core of the imaged pre-BötC (B), slows and then stops network oscillations with time course dependent on TTX concentration. Immediate recovery occurs on bath washout or discontinuation of local microinfusion. C, Frequency (left) and amplitude (right) of network activity are both reduced, but frequency is predominately affected by local microinfusion or bath application of TTX.