Figure 7.

Perturbations of network oscillations in isolated pre-BötC island preparations by low concentrations of TTX. A, Bath-applied TTX (20 nm) rapidly reduces the frequency and then stops network oscillations as recorded electrophysiologically from the pre-BötC population. Integrated pre-BötC population activity (∫pre-BötC) is shown from a representative island preparation. B, Frequency (left) and amplitude (right) of network activity are both reduced in the group of islands studied, but frequency is predominately affected by bath-applied TTX, similar to perturbations of inspiratory network activity in the intact slices (compare with Fig. 6).