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. 2019 Jul 24;25:5482–5492. doi: 10.12659/MSM.915251

Figure 5.

Figure 5

The contribution of rL-RVG, α7-nAChR antagonist MLA, agonist ACB, or siRNA downregulation to the expression of α7-nAChR, p-AKT, PI3K, and apoptosis-associated proteins in HGC cells after infection. (A) For α7-nAChR antagonist. (B) For α7-nAChR agonist. (C) For α7-nAChR siRNA. When the groups were pretreated with α7-nAChR antagonist MLA, the expression of Bax/Bcl-2 and cleaved caspase 3 proteins increased in HGC cells compared to cells without MLA or α7-nAChR siRNA treatment (** P<0.01), except for the rL-RVG +MLA group and the rL-RVG group. The expression of the Bax/Bcl-2 and cleaved caspase 3 proteins decreased significantly (** P<0.01) in cells with α7-nAChR agonist ACB treatment compared with cells without pretreatment. The expression of α7-nAChR proteins decreased in MLA-pretreated groups (** P<0.01), but increased in ACB-pretreated groups (** P<0.01). The expression of p-AKT and PI3K proteins decreased in MLA and α7-nAChR siRNA-pretreated groups (** P<0.01), except for the rL-RVG group and the pretreated groups, but increased in the ACB-pretreated groups (** P<0.01). * P<0.05.