Table 1.
WT |
Gabra5/Gabrd−/− |
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
CA1 PC | CA3 PC | DGGC | CA1 PC | CA3 PC | DGGC | |||||||
sIPSCs | sEPSCs | sIPSCs | sEPSCs | sIPSCs | sEPSCs | sIPSCs | sEPSCs | sIPSCs | sEPSCs | sIPSCs | sEPSCs | |
Imean (pA/sec) | 2.25 ± 0.36 | 0.37 ± 0.04 | 11.8 ± 2.0 | 1.86 ± 0.59 | 1.96 ± 0.72 | 0.32 ± 0.03 | 2.04 ± 0.47 | 0.42 ± 0.05 | 17.2 ± 2.98 | 2.19 ± 0.40 | 1.17 ± 0.41 | 0.32 ± 0.08 |
Frequency (Hz) | 20.8 ± 3.04 | 3.13 ± 0.71 | 39.0 ± 3.12 | 15.1 ± 0.82 | 12.8 ± 3.67 | 4.84 ± 1.10 | 20.9 ± 3.06 | 4.35 ± 0.64 | 40.0 ± 2.17 | 19.0 ± 2.76 | 10.6 ± 2.45 | 2.81 ± 0.58 |
Peak amplitude (pA) | 15.8 ± 0.40 | 14.9 ± 1.04 | 32.6 ± 3.04 | 19.5 ± 3.10 | 18.4 ± 1.86 | 12.2 ± 0.28 | 16.2 ± 0.87 | 14.7 ± 1.59 | 41.9 ± 5.59 | 20.1 ± 1.55 | 16.5 ± 1.38 | 11.6 ± 0.94 |
RT10–90 (ms) | 0.78 ± 0.03 | 0.81 ± 0.03 | 1.72 ± 0.09 | 1.15 ± 0.06 | 1.17 ± 0.07 | 0.88 ± 0.05 | 0.69 ± 0.03 | 0.67 ± 0.07 | 1.76 ± 0.08 | 1.22 ± 0.08 | 1.21 ± 0.08 | 0.95 ± 0.03 |
Tw (ms) | 8.45 ± 0.14 | 5.53 ± 0.36 | 9.82 ± 0.39 | 6.27 ± 0.23 | 8.05 ± 0.29 | 4.92 ± 0.14 | 8.22 ± 19 | 5.62 ± 0.17 | 10.7 ± 0.38 | 6.65 ± 0.19 | 8.2 ± 0.34 | 4.78 ± 0.24 |
n | 5 | 5 | 8 | 8 | 7 | 7 |
Imean, sIPSCs, and sEPSCs recorded in aCSF with a low Cl− pipette solution.