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. 2008 Feb 6;28(6):1374–1384. doi: 10.1523/JNEUROSCI.3632-07.2008

Figure 3.

Figure 3.

Chronic but not subchronic fluoxetine enhances dendritic complexity of DCX+ cells. A, Representative image and traces from Sholl analyses of DCX+ cells with tertiary branches after vehicle (Veh), subchronic fluoxetine (5d Flx), and chronic fluoxetine (28d Flx) (n = 5 mice per group, 10–12 cells per mouse). B, Chronic but not subchronic fluoxetine increased dendritic length (ANOVA, F (2,12) = 10.11, p = 0.003 for treatment). We also detected a treatment × radius interaction (F (38,228) = 2.17, p < 0.001). Fisher's post hoc analysis revealed significant difference between vehicle- and chronic-treated groups (*p < 0.05). C, Chronic but not subchronic fluoxetine increased the number of intersections of DCX+ cells (ANOVA, F (2,12) = 9.13, p = 0.004 for treatment). We also detected a treatment × radius interaction (F (38,228) = 1.48, p < 0.001). Fisher's post hoc analysis revealed significant difference between vehicle- and chronic-treated groups (*p < 0.05). D–G, Representing images and traces from Sholl analysis of 3-week-old DCX+BrdU+ cells after 3 weeks of fluoxetine treatment. Hippocampal sections were double stained for DCX (D) and BrdU (E), and double-positive cells (F) were chosen to perform Sholl analysis on (n = 5 mice per group, 4–8 cells per mouse). H, Three weeks of fluoxetine (21d Flx) increased dendritic length compared with the vehicle group (Veh) (ANOVA, F (1,8) = 17.68, p = 0.003). We also detected a treatment × radius interaction (F (1,18) = 2.68, p = 0.0006). Fisher's post hoc analysis revealed significant difference between vehicle- and chronic-treated groups (*p < 0.05). I, Chronic fluoxetine also increased the number of intersections (ANOVA, F (1,8) = 21.68, p = 0.002). We also detected a treatment × radius interaction (F (1,18) = 2.34, p = 0.003). Fisher's post hoc analysis revealed significant difference between vehicle- and chronic-treated groups (*p < 0.05).