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. 2008 Feb 6;28(6):1374–1384. doi: 10.1523/JNEUROSCI.3632-07.2008

Figure 6.

Figure 6.

Behavioral effects of fluoxetine depend on adult neurogenesis. Novelty-suppressed feeding test on day 5 (A, B) and day 28 (C, D) of vehicle (Veh) or fluoxetine treatment. A, Five days of fluoxetine (5d Flx) did not reduce latency to feed in sham (Sham) or x-irradiated (x-ray) animals (Cum. Survival, cumulative survival, percentage of animals that have not eaten) (Kaplan–Meier survival analysis, Mantel–Cox log-rank test, p > 0.05). B, Box plot of latency to feed after 5 d of vehicle or fluoxetine. C, Twenty-eight days of fluoxetine (28d Flx) reduced latency to feed in sham but not x-ray animals (Kaplan–Meier survival analysis, Mantel–Cox log-rank test, p = 0.038 for treatment; *p < 0.05 between sham fluoxetine and the other three groups; p > 0.05 for all other groups). D, Box plot of latency to feed after 28 d of fluoxetine treatment. The box plot displays 10, 25, 50, 75, and 90% percentiles.