Figure 9.

Mechanical allodynia and antinociception in CRP2^−/− mice induced by cGMP analogs. 8-Br-cGMP or 8-pCPT-cGMP was administered onto the lumbar spinal cord via an intrathecal catheter. Thereafter, the withdrawal latency time of a hindpaw after mechanical stimulation by an automated device was measured at the indicated time points. Data were normalized to baseline latency times and are presented as mean percentage ± SEM; n = 6 per compound and genotype. A, “High-dose” 8-Br-cGMP (250 nmol). B, “High-dose” 8-pCPT-cGMP (25 nmol). C, “Low-dose” 8-Br-cGMP (25 nmol). D, “Low-dose” 8-pCPT-cGMP (1.25 nmol).