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Expression of apoE-I3 in mouse brains in response to excitotoxic injury induced by kainic acid (KA). A, B, In situ hybridization of apoE-I3 mRNA in control (A) and KA-treated (B) human apoE knock-in mice. C, RT-PCR of apoE-I3 using a serial dilution of total RNA from the brains of KA-treated and untreated mice as templates. D, qRT-PCR of apoE-I3 in the hippocampus (Hippo) and cortex of control (Con) and KA-treated mice (n = 3; *p < 0.001 vs the corresponding control).
