Figure 1.
Tonic inhibition is observed in K-gluconate-based intracellular solution and is due to GABAA rather than glycine or GABAB receptor activation. A, Recording from an SPN holding at resting membrane potential showing 100 μm bicuculline (Bic, line) slightly increased cell input resistance without changing membrane potential. B, Trace from the same cell when holding at 0 mV before and after application of 1 μm TTX, again the lines denote application of bicuculline. C, A similar response was also observed with picrotoxin (Pic) but not the glycine receptor antagonist strychnine (Stry) or the GABAB receptor antagonist CGP55458A (D).