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. 2008 Nov 19;28(47):12477–12488. doi: 10.1523/JNEUROSCI.3240-08.2008

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Copyright © 2008 Society for Neuroscience 0270-6474/08/2812477-12$15.00/0

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Figure 6. — Chronic inflammatory environment leads to more action potential-dependent inhibitory drive in new than in mature neurons. Whole-cell voltage-clamp recordings of sIPSCs (in the presence of NBQX plus d-AP5) and mIPSCs (after addition of TTX) in cells from vehicle-treated (A, D) and LPS-treated (B, C, E, F) animals. Cumulative fraction curves showing sIPSCs at similar IEIs in new and mature cells in vehicle-treated animals (A) (p > 0.05) but with shorter IEIs (B) (p < 0.001) in new cells compared with mature cells in LPS-treated animals. C, Higher amplitude of sIPSCs in new cells compared with old cells in LPS animals (p < 0.001). Similar IEIs of mIPSCs in new and mature cells in vehicle-treated animals (D) (p > 0.05), and similar IEIs (E) (p > 0.05) and amplitudes (F) (p > 0.05) of mIPSCs in new cells compared with mature cells in LPS-treated rats after action potential blockade with TTX (Kolmogorov–Smirnov test). The cells are the same as in Figure 5.