Figure 7.
Chronic inflammatory environment does not influence short-term plasticity at inhibitory synapses in new neurons. A, Representative recordings (each trace is average of 20 responses from the same cell) from new cells in vehicle- and LPS-treated animals before (“−BAC”; B1) and after (“+BAC”; B2) addition of the GABAB receptor agonist baclofen. Baclofen eliminated PPD similarly in new cells from vehicle (B) and LPS (C) animals. B, C, Depression/facilitation of IPSCs in individual cells; each cell is plotted before and after baclofen addition (connected with dashed lines), and group averages are depicted by the solid line (n = 5 and 7 cells in LPS- and vehicle-treated animals, respectively). *p < 0.05, Student's paired t test. Recordings were performed 6.1–7.7 weeks after RV-GFP injection. Calibration: A1, 50 ms, 100 pA; A2, 50 ms, 50 pA.