Figure 8.

New neurons born into a chronic inflammatory environment develop normal spine density and morphology but increased size of the postsynaptic scaffolding protein gephyrin. New neurons develop dendritic tree with thin (open square), stubby (closed square), filopodia (closed circle), and mushroom spines (open circle) (A), and with similar density of dendritic spines (B) and mushroom spines (C) in vehicle- and LPS-treated animals in inner and outer ML (iML and oML, respectively). New neurons born in vehicle-treated (D) or LPS-treated (E) animals develop gephyrin clusters on dendrites (arrows), with similar density (F) but increased size (G) on distal dendrites in outer ML of LPS-treated compared with vehicle-treated animals (*p < 0.001) (Student's unpaired t test) (LPS, n = 23–34 dendrites; vehicle, n = 21–33 dendrites). Error bars indicate SEM. Scale bars: A, D (for D, E), 1 μm.