Table 1.

Genotypes and transgene expression levels among the various transgenic lines

Name	PS1M146VKI	hAPP	htau	Expression of hAPP over endogenous	Expression of htau over endogenous
3xTg-AD	+/+	+/+	+/+	∼6×	∼6×
APP/tau	−/−	+/+	+/+	∼6×	∼6×
PS1/tau	+/+	−/−	+/−	N/A	∼6×
NonTg	−/−	−/−	−/−	N/A	N/A

The table shows the genotype and the relative expression levels of all the mice used in this study. Notably, because of the way we derived the mice, all the groups are on the same genetic background (C57BL6/129sv). The characterization of the 3xTg-AD, the PS1/tau, and the NonTg mice was previously described (Oddo et al., 2003b).