Figure 3.

Histological changes after 2 h of ICMS compared with the contralateral side. a, b, Changes at the stimulation site in c-Fos and in PV. A dark arrow indicates the electrode track. c, Increase of the excitatory system (glutamate) after 2 h of ICMS 1 mm lateral the ICMS electrode. The small right top image shows a magnification of stained pyramidal cell. d, e, Enhancement of inhibitory system after 2 h of ICMS in GABA and GAD 500 μm rostral the ICMS electrode. In the small windows of the GAD images at a higher magnification, a nonlabeled pyramidal cell is shown, which is surrounded by labeled GAD puncta. (For magnification, see scale bar in a).