Figure 7.

Minimal size recovery of the E16.5 Atrx-null forebrain in the absence of p53. A, H&E sections of E16.5 forebrain shows that loss of p53 does not ameliorate forebrain size, except in the caudal-medial area (indicated by *). Scale bar, 500 μm. B, Measurements of cortical plate thickness, brain height and hippocampal area confirm size reductions in the Atrx^Foxg1Cre embryos but show no significant amelioration in the Atrx^Foxg1Cre:p53^−/− embryos. C, Partial recovery of medial cortical size is suggested by the decreased distance between the left and right cingulate cortex in the Atrx^Foxg1Cre:p53^−/− compound mutants compared with the Atrx^Foxg1Cre embryos (* in A). H, Hippocampus; Cx, cortex. n = 3 for all genotypes except for Atrx^Foxg1Cre:p53^+/+ where n = 2. All distances are measured in micrometers unless otherwise indicated.