Figure 8.
Partial rescue of ATRX-null forebrain size upon loss of p53 at E18.5 and P0.5. A, H&E sections of E18.5 forebrain showing partial size recovery of the hippocampus and cortex in the AtrxFoxg1Cre:p53+/− and AtrxFoxg1Cre:p53−/− compared with AtrxFoxg1Cre embryos. B, Size differences were measured as indicated in the inset (parameters 1–3) in two different caudal areas of the forebrain (C) Partial forebrain size recovery was also observed at P0.5 (top). Higher magnification micrographs show minimal rescue of cellularity in the dentate gyrus in the AtrxFoxg1Cre:p53−/− compound mutants (middle), and accumulation of dentate precursors in the dentate neuroepithelium (bottom, arrows). Scale bar, 100 μm. H, Hippocampus; Cx, cortex.