Figure 5.

The inhibitory effect of hRANTES on glutamate release from human neocortical synaptosomes involves adenylyl cyclase activity. A, Effects of PTx and 8-Br-cAMP on the K⁺-evoked release of glutamate from human neocortical synaptosomes in absence or in presence of hRANTES. Results are expressed as percentage of induced overflow. Data are means ± SEM of four experiments run in triplicate. *p < 0.05 versus control; ^# p < 0.05 versus 12 mm K⁺/1 nm hRANTES. B, Effects of hRANTES and MDL-12,330A on the release of glutamate elicited by forskolin from human neocortical synaptosomes. Results are expressed as percentage of induced overflow. Data are means ± SEM of three experiments run in triplicate. *p < 0.05 versus control.