Table 2.

Effects of hRANTES and met-RANTES on the spontaneous and the K⁺-evoked release of [³H]d-aspartate from human neocortical slices

	[3H]d-aspartate release (% induced overflow)
	Control	1 nm hRANTES	1 nm met-RANTES
Basal	0.02 ± 0.04	0.31 ± 0.13	0.08 ± 0.07
30 mm K+	1.24 ± 0.20	0.64 ± 0.11*	1.07 ± 0.11
50 mm K+	10.69 ± 1.11	6.47 ± 0.68*	9.22 ± 0.45

When studying the effect of hRANTES or met-RANTES on basal release, the compounds were applied starting at t = 70 min for 5 min. When the effects of hRANTES or met-RANTES on the K⁺-evoked release were analyzed, the depolarizing stimulus was applied in absence or in presence of the peptides at t = 70 min for 5 min, then replaced with standard medium. Results are expressed as percent induced overflow; data are means ± SEM of three to four experiments run in triplicate.

*p < 0.05 versus respective control.