Figure 6.

The effects of changes in the spatial relations between distal and proximal cues on the hippocampal place-related activity in D1R-KO mice in the familiar (1–5) and novel environments (6–10). A, A typical place cell had a place field that did not follow the rotation of the distal cues (1–2), but followed the rotation of the proximal cues (3–4) in the familiar environment. In the novel environment, the place field of this cell was not changed by either the distal or the proximal cue manipulations. B, Another example of a place cell whose place-related activity did not follow the rotation of the distal cues (1–2) but did follow the rotation of the proximal cues (3–4) in the familiar environment, and this cell responded similarly in the novel environment (6–10). Note that no place cells in D1R-KO mice followed the change in the distal cues. Other descriptions are as those for Figure 2.