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. 2008 Dec 10;28(50):13662–13672. doi: 10.1523/JNEUROSCI.4144-08.2008

Figure 2.

Figure 2.

Expression patterns of huntingtin. A, Western blot assays of primary cortical and striatal neurons. BDNF is expressed in cortical but not striatal neurons. Striatal neurons express high level of GAD67 and DARPP32 proteins. B, Expression of wild-type and mutant huntingtin in transfected primary cortical neurons. C, Expression of wild-type and mutant huntingtin in transfected primary striatal neurons. D, Western blot assay of soluble protein levels of wild-type (W.T.) and Hdh150Q/150Q mouse brains. There is no significant difference in the level of huntingtin, p150Glued, DHC, or KHC. The level of BDNF is lower in Hdh150Q/150Q mice. Tub, Tubulin.