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. 2008 Dec 10;28(50):13662–13672. doi: 10.1523/JNEUROSCI.4144-08.2008

Figure 6.

Figure 6.

Retrograde BDNF transport is disrupted in striatal but not cortical neurons of homozygous Hdh150Q mice. A, Endogenous mutant huntingtin does not affect velocity of either anterograde or retrograde BDNF-mCherry movement in primary cortical neurons. Anterograde, 1.23 versus 1.06 μm/s, p > 0.05; retrograde, 0.72 versus 0.2 μm/s, p > 0.05. B, Endogenous mutant huntingtin does not change the distribution BDNF-mCherry moving particles in primary cortical neurons. C, Endogenous mutant huntingtin reduces the velocity of retrograde BDNF-mCherry movement in primary striatal neurons. Anterograde, 0.74 versus 0.64 μm/s, p > 0.05; retrograde, 0.86 versus 0.56 μm/s, p = 0.03. D, Endogenous mutant huntingtin increases the number of stationary BDNF-mCherry particles in primary striatal neurons. Anterograde, 30 versus 15%, p < 0.05; retrograde, 32 versus 10%, p < 0.05; stationary, 38 versus 65%, p < 0.05. W.T., Wild type; N.S., not significant. *p < 0.05. Error bars indicate SE.