Retrograde BDNF transport is disrupted in striatal but not cortical neurons of homozygous Hdh150Q mice. A, Endogenous mutant huntingtin does not affect velocity of either anterograde or retrograde BDNF-mCherry movement in primary cortical neurons. Anterograde, 1.23 versus 1.06 μm/s, p > 0.05; retrograde, 0.72 versus 0.2 μm/s, p > 0.05. B, Endogenous mutant huntingtin does not change the distribution BDNF-mCherry moving particles in primary cortical neurons. C, Endogenous mutant huntingtin reduces the velocity of retrograde BDNF-mCherry movement in primary striatal neurons. Anterograde, 0.74 versus 0.64 μm/s, p > 0.05; retrograde, 0.86 versus 0.56 μm/s, p = 0.03. D, Endogenous mutant huntingtin increases the number of stationary BDNF-mCherry particles in primary striatal neurons. Anterograde, 30 versus 15%, p < 0.05; retrograde, 32 versus 10%, p < 0.05; stationary, 38 versus 65%, p < 0.05. W.T., Wild type; N.S., not significant. *p < 0.05. Error bars indicate SE.