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Nerve injury induces the upregulation of IL-18 in macrophages in injured L5 DRG. A, IL-18 immunostaining in the naive DRG and the ipsilateral and contralateral (Contra) L5 DRG at days 1, 3, 7, and 14 after L5 SNL. B, Double immunostaining of green reaction product for IL-18 and red product for macrophage marker ED-1 in the L5 DRG at day 7. Scale bars, 100 μm.
