Figure 6.
IL-18R blockade attenuates tactile allodynia induced by peripheral nerve injury. A, Pretreatment with anti-IL-18R antibodies (10 or 100 ng · μl−1 · h−1) attenuated mechanical hypersensitivity induced by nerve injury. Tactile allodynia was determined with a Dynamic Plantar Aesthesiometer at days 1, 3, 5, and 7 after nerve injury. B, Pretreatment with anti-IL-18R antibodies did not change the threshold on the contralateral hindpaw. For control experiments, either PBS or IgG was used. BL, Baseline; Ab, antibody. Data represent mean ± SEM; n = 8 per group. #p < 0.05, compared with the vehicle control group; ##p < 0.01, compared with the vehicle control group; ###p < 0.001 compared with the vehicle control group.