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. 2008 Nov 26;28(48):12775–12787. doi: 10.1523/JNEUROSCI.3512-08.2008

Figure 9.

Figure 9.

Induction of behavioral allodynia and spinal astroglial markers by IL-18 through the NFκB pathway. A, Intrathecal administration of IL-18 induced tactile allodynia at day 1 in a dose-dependent manner. *p < 0.05, compared with the vehicle control group; **p < 0.01, compared with the vehicle control group. B, Time course for IL-18-induced tactile allodynia. **p < 0.01, compared with the pre-operative value; ***p < 0.001, compared with the preoperative value. C, Attenuation of IL-18 action by pretreatment with a NFκB inhibitor, SN50. **p < 0.01, compared with the vehicle control group; ###p < 0.001, compared with the IL-18 group. D, Spinal injection of both IL-18 and IL-1β (50 ng) induced tactile allodynia at 3 and 6 h after injection. *p < 0.05, compared with the preoperative value; ***p < 0.001, compared with the preoperative value. For control experiments, PBS was used. Data represent mean ± SEM; n = 8 per group. BL, Baseline.