Figure 4.

Effect of viral-mediated overexpression of ATF2, ATF3, or ATF4 in nucleus accumbens on spontaneous and amphetamine-stimulated locomotor activity. Time course of spontaneous locomotor activity for HSV-ATF2 (a), -ATF3 (b), and -ATF4 (c) and saline-induced activity. Bottom panels show amphetamine-stimulated locomotor activity (2 mg/kg, i.p.) 3 d after bilateral intra-NAc injections of HSV-ATF2 (d), -ATF3 (e), or -ATF4 (f) when transgene expression is maximal. Control animals received injections of HSV-GFP. Points represent mean ± SEM beam breaks in 10 min bins (n = 6–8). Rats were allowed 60 min to habituate to the test chamber before amphetamine was injected.