Table 1.

Effects of Ro64–6198 and MK-801 administered alone or concurrently on basal PERK and P-JNK levels in the hippocampus

Treatment	P-ERK (% control)	P-JNK (% control)
Ro64-6198 (mg/kg, i.p.)
Vehicle (n = 4)	100 ± 30	100 ± 15
0.3 (n = 4)	101 ± 18	73 ± 14
1 (n = 4)	110 ± 12	75 ± 17
3 (n = 4)	93 ± 22	87 ± 8
MK-801 (mg/kg, s.c.)
Vehicle (n = 4)	100 ± 21	100 ± 15
0.1 (n = 5)	89 ± 27	102 ± 12
0.3 (n = 4)	36 ± 8*	38 ± 5*
Ro64-6198 + MK-801
Vehicle (n = 4)	100 ± 19	100 ± 4
1 + 0.1 mg (n = 4)	71 ± 36	77 ± 18

Mice were given Ro64–6198 or MK-801 injections separately or concurrently in the home cage, and changes in basal P-ERK and P-JNK levels were assessed 30 min later. Data are expressed as mean ± SEM.

*p < 0.05 versus vehicle-treated group.