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. 2008 Feb 27;28(9):2168–2178. doi: 10.1523/JNEUROSCI.5232-07.2008

Figure 9.

Figure 9.

Salubrinal increases phosphorylation of eIF-2a and prevents LTIH upregulation of CHOP/GADD153. A, Fluorescence photomicrograph of p-eIF-2a immunoreactivity (Alexa Fluor 594; red color) and ChAT immunoreactivity (Alexa Fluor 488; green color) in facial neurons. Salubrinal increased p-eIF-2a immunoreactivity relative to background in both the VII (vehicle, 1.3 ± 0.03, vs salubrinal, 1.5 ± 0.05; t = 4.5; p < 0.001) and the XII nuclei (vehicle, 1.2 ± 0.03, vs salubrinal, 1.5 ± 0.04; t = 5.1; p < 0.001). B, Fluorescence photomicrograph of CHOP/GADD153 immunoreactivity (Alexa Fluor 594; red color) and ChAT immunoreactivity (Alexa Fluor 488; green color) in hypoglossal neuron. CHOP/GADD153 immunoreactivity as suppressed in salubrinal-treated mice exposed to LTIH. Scale bar, 50 mm.