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. 2019 Jul 17;3(8):1036–1049. doi: 10.1002/hep4.1381

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© 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Multiple pathways of HFD‐mediated steatosis are down‐regulated in livers of GLKO mice. (A) Heat map of the RNA‐Seq analyses of gene expression in livers of WT and GLKO mice untreated and treated with the HFD. Right image shows labels of conditions, genotype, and diet. (B) Numbers and overlap of genes that are changed in WT and GLKO mice by an HFD. (C) Comparisons of signaling pathways that are up‐ or down‐regulated by an HFD in WT (upper) and GLKO mice (bottom). Red circles show pathways associated with NAFLD. Abbreviations: Down, down‐regulated; NADPH, nicotinamide adenine dinucleotide phosphate (reduced); PPAR, peroxisome proliferator‐activated receptor; Up, up‐regulated.