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Summary of our work with genetically modified animal models demonstrating a critical role of proliferation in HFD‐mediated spontaneous fibrosis and liver cancer. (A) Summary of WT and GLKO mice on an ND versus an HFD study conclusions. (B) Data summary of aging CUGBP1 KI mice. (C) Summary of recent work25 with C/EBPα‐S193A mice demonstrating similar mechanisms. Abbreviations: Down, down‐regulated; mo, months; UP, up‐regulated.
