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. 2019 Aug 1;10:3455. doi: 10.1038/s41467-019-11119-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Cyfip1 haploinsufficient rats show deficits in flexible responses in orienting behaviour on a mismatch task. a There are no genotype effects on habituation to the experimental apparatus. Both WT (n = 21) and Cyfip1^+/− (n = 15) show reduced activity to the experimental chambers over the course of each 30-min long session (5 min blocks). b Both WT and Cyfip1^+/− rats showed reduced orienting to the auditory-visual sequences presented during training (ANOVA: F(1,34) = 2.4, p = 0.62), and c WT rats preferentially responded to the novel mismatched visual stimuli over the familiar matched stimuli (discrimination ratio <0.50). In contrast, Cyfip1^+/− rats showed no preference, responding equally to both matched and mismatched visual cues (ANOVA: F(1,34) = 5.92,*). *<0.05, **<0.01, ***<0.001. Source data are provided as a Source Data file