Table 2.
Associations between CSF/MRI measures and cognition. Linear regression models with cognitive measures as dependent variables and CSF/MRI measures as independent variables. Model 1: unadjusted. Model 2: controlling for age, sex, and education, and for hippocampal volume also total intracranial volume. Standardized beta coefficients with p values (unadjusted and false discovery rate (FDR) adjusted in parentheses) are presented. Abbreviations: ADAS, Alzheimer’s disease assessment scale; CSF, cerebrospinal fluid; Aβ, amyloid-β; MRI, magnetic resonance imaging; WML, white matter lesion; ctx, cortex.
| ADAS Cog delayed recall | Attention/executive composite score | |||||||
|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 1 | Model 2 | |||||
| β | p | β | p | β | p | β | p | |
| CSF MEASURES | ||||||||
| Aβ positivity | −0.15 | 0.009 | −0.14 | 0.013 (0.062) | −0.051 | 0.38 | −0.020 | 0.70 (0.81) |
| P-tau | −0.15 | 0.012 | −0.11 | 0.061 (0.19) | −0.13 | 0.027 | −0.023 | 0.67 (0.81) |
| T-tau | −0.13 | 0.021 | −0.097 | 0.099 (0.24) | −0.14 | 0.018 | −0.025 | 0.64 (0.81) |
| YKL-40 | −0.13 | 0.026 | −0.073 | 0.22 (0.44) | −0.092 | 0.11 | 0.046 | 0.40 (0.63) |
| MRI MEASURES | ||||||||
| WML volume | −0.14 | 0.020 | −0.030 | 0.64 (0.81) | −0.25 | <0.001 | −0.098 | 0.086 (0.24) |
| Hippocampal volume | 0.21 | <0.001 | 0.27 | <0.001 (0.011) | 0.33 | <0.001 | 0.16 | 0.014 (0.062) |
| Entorhinal/parahippocampal ctx | 0.28 | <0.001 | 0.22 | <0.001 (0.011) | 0.22 | <0.001 | 0.043 | 0.46 (0.67) |
| Temporal ctx | 0.24 | <0.001 | 0.16 | 0.012 (0.062) | 0.21 | <0.001 | −0.003 | 0.96 (0.98) |
| Frontal ctx | 0.22 | <0.001 | 0.14 | 0.022 0.081) | 0.16 | 0.005 | 0.002 | 0.98 (0.98) |
| Parietal ctx | 0.16 | 0.006 | 0.083 | 0.17 (0.37) | 0.16 | 0.007 | 0.004 | 0.94 (0.98) |
| Occipital ctx | 0.13 | 0.030 | 0.051 | 0.40 (0.63) | 0.18 | 0.001 | 0.059 | 0.28 (0.51) |