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. 2019 Aug 1;9:11187. doi: 10.1038/s41598-019-47593-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of ΔΨ_m heterogeneity by inhibition of mechanotransduction. (A,B) TMRM fluorescence in monoculture µTSA on day 4 treated with inhibitors of mechanotransduction: Y-27632 (50 μM, ROCK inhibitor) and Latrunculin A (LatA, 0.5 μM, actin polymerization inhibitor) from 30 to 240 minutes. Scale bar: 500 μm; (C,D) Changes of TMRM fluorescence in cancer cells at the center and edge as a function of treatment time (Representative dataset from N = 3 independent experiments; *p < 0.05, ***p < 0.001, ****p < 0.0001, by ordinary one-way ANOVA).