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. 2019 Aug 1;9:11213. doi: 10.1038/s41598-019-47229-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Co-culture and EVs neuronal induction modulating the neurogenic transcript levels. (a) Heatmap with hierarchical grouping and analysis of the main genes related with the neurogenesis, showing the differences between ADSC induced or not and brain cells on D3. (b) Heatmap with hierarchical grouping and analysis of the main genes related with the neurogenesis, showing the ADSC-CC D7 as the most similar to BRC. (c) miRNAs studied in the ADSC induced into neuron-like cells by co-culture or by extracellular vesicles on day 3. There was more expression of miR-184, miR-137, miR-124 and miR-132 in neurons than the other cells types. ADSC-CC showed more expression of miR-184 than the other stem cells, and ADSC + BRCMV D3 showed more expression of miR-9 than the other cells type. ADSC-CC D3 had similar miRNAs levels than ADSC D3, and miR-132 expression was similar in all stem cells. (d) miRNAs studied in the ADSC induced into neuron-like cells by co-culture or by extracellular vesicles on day 7. There was more expression of miR-195, miR-184, miR-137, miR-124 and miR-132 in BRC than the other groups. Different letters of the same graph indicate statically difference between the groups. (p ≤ 0.05). ND- no detectable.