Table 2.
1H-MRS metabolite concentrations corrected for voxel cerebrospinal fluid (CSF) content, and 1H-MRS voxel % of white matter, grey matter and CSF, at three timepoints
| Healthy volunteers n = 15 | Total patient group n = 23 | Non-Remission n = 11 | Remission n = 12 | |
|---|---|---|---|---|
| Baseline 1H-MRS Scan | ||||
| Anterior cingulate cortex | ||||
| Glx | 20.76 (2.96) | 19.99 (3.29) | 19.85 (3.48) | 20.12 (3.27) |
| Glu | 14.04 (1.36) | 14.11 (1.61) | 13.87 (1.23) | 14.33 (1.92) |
| NAA | 12.24 (1.19) | 11.97 (1.35) | 11.98 (1.30) | 11.97 (1.46) |
| Cho | 2.77 (0.51) | 2.80 (0.34) | 2.83 (0.46) | 2.76 (0.19) |
| mI | 7.95 (1.62) | 7.75 (1.28) | 7.77 (1.25) | 7.74 (1.37) |
| Cr | 10.29 (1.24) | 10.46 (1.17) | 10.34 (1.29) | 10.57 (1.10) |
| White matter | 12.54 (0.04) | 12.36 (0.04) | 13.19 (0.04) | 11.61 (0.03) |
| Grey matter | 66.43 (0.06) | 65.00 (0.04) | 64.95 (0.05) | 65.04 (0.04) |
| CSF | 20.99 (0.04) | 22.63 (0.05) | 21.83 (0.05) | 23.35 (0.05) |
| Left Thalamus | ||||
| Glx | 11.04 (2.53) | 10.30 (2.10) | 10.04 (1.62) | 10.54 (2.52) |
| Glu | 8.13 (1.01) | 8.06 (1.33) | 7.96 (0.61) | 8.15 (1.78) |
| NAA | 11.31 (1.29) | 11.57 (0.72) | 11.73 (0.84) | 11.43 (0.61) |
| Cho | 2.18 (0.29) | 2.08 (0.18) | 2.14 (0.17) | 2.02 (0.18) |
| mI | 4.21 (0.82) | 4.08 (0.55) | 4.16 (0.39) | 4.01 (0.68) |
| Cr | 7.37 (0.64) | 7.53 (0.59) | 7.48 (0.54) | 7.57 (0.65) |
| White matter | 73.94 (0.08) | 77.09 (0.06) | 79.19 (0.06) | 75.17 (0.06) |
| Grey matter | 25.67 (0.08) | 22.51 (0.06) | 20.24 (0.05) | 24.57 (0.06) |
| CSF | 00.37 (0.01) | 00.40 (0.01) | 00.56 (0.01) | 00.25 (0.00) |
| 6 weeks 1H-MRS Scan | ||||
| Anterior cingulate cortex | ||||
| Glx | 19.70 (3.46) | 20.34 (2.95) | 20.02 (2.68) | 20.63 (3.26) |
| Glu | 13.18 (1.74) | 14.13 (2.01) | 14.07 (2.18) | 14.18 (1.94) |
| NAA | 12.43 (1.22) | 12.43 (1.28) | 12.36 (0.90) | 12.49 (1.59) |
| Cho | 2.73 (0.44) | 2.90 (0.44) | 2.97 (0.24) | 2.83 (0.57) |
| mI | 8.09 (1.41) | 8.17 (1.42) | 8.22 (1.16) | 8.12 (1.67) |
| Cr | 10.42 (1.06) | 10.88 (1.27) | 10.85 (0.72) | 10.90 (1.65) |
| White matter | 10.53 (0.03) | 11.06 (0.02) | 11.23 (0.02) | 10.91 (0.03) |
| Grey matter | 66.64 (0.04) | 65.55 (0.05) | 65.34 (0.04) | 65.74 (0.05) |
| CSF | 22.90 (0.05) | 23.37 (0.05) | 23.40 (0.05) | 23.34 (0.06) |
| Left Thalamus | ||||
| Glx | 9.63 (2.61) | 9.65 (1.77) | 9.56 (1.61) | 9.73 (1.98) |
| Glu | 7.57 (1.79) | 7.26 (1.07) | 7.28 (0.90) | 7.23 (1.24) |
| NAA | 11.71 (0.69) | 11.26 (0.71) | 11.26 (0.70) | 11.25 (0.76) |
| Cho | 2.22 (0.23) | 2.06 (0.17)* | 2.10 (0.16) | 2.02 (0.18) |
| mI | 4.28 (0.64) | 4.10 (0.78) | 4.14 (0.97) | 4.05 (0.61) |
| Cr | 7.55 (0.68) | 7.38 (0.48) | 7.43 (0.39) | 7.34 (0.56) |
| White matter | 77.47 (0.09) | 80.30 (0.05) | 79.84 (0.05) | 80.72 (0.05) |
| Grey matter | 22.34 (0.09) | 19.49 (0.05) | 19.91 (0.05) | 19.10 (0.05) |
| CSF | 00.25 (0.00) | 00.19 (0.00) | 00.22 (0.00) | 00.15 (0.00) |
| 9 month 1H-MRS Scan | ||||
| Anterior cingulate cortex | ||||
| Glx | 20.58 (3.32) | 20.13 (2.26) | 20.45 (2.60) | 19.83 (1.97) |
| Glu | 14.19 (2.43) | 13.65 (2.03) | 13.61 (1.93) | 13.68 (2.19) |
| NAA | 12.24 (1.23) | 12.05 (1.21) | 12.16 (1.21) | 11.95 (1.26) |
| Cho | 2.76 (0.35) | 2.73 (0.29) | 2.75 (0.38) | 2.71 (0.19) |
| mI | 7.47 (1.15) | 7.88 (1.02) | 8.13 (1.22) | 7.65 (0.78) |
| Cr | 10.34 (1.31) | 10.33 (0.68) | 10.26 (0.73) | 10.40 (0.64) |
| White matter | 10.43 (0.03) | 12.98 (0.04) | 13.35 (0.04) | 12.64 (0.03) |
| Grey matter | 66.93 (0.04) | 64.58 (0.05) | 63.61 (0.06) | 65.45 (0.04) |
| CSF | 22.61 (0.04) | 22.42 (0.04) | 23.02 (0.04) | 21.88 (0.04) |
| Left Thalamus | ||||
| Glx | 10.14 (1.92) | 10.60 (1.93) | 11.46 (1.45) | 9.75 (2.02)* |
| Glu | 7.70 (1.43) | 8.31 (1.24) | 8.60 (0.89) | 8.03 (1.51) |
| NAA | 11.05 (0.96) | 11.54 (1.46) | 11.48 (1.71) | 11.61 (1.26) |
| Cho | 2.05 (0.39) | 2.12 (0.36) | 2.21 (0.45) | 2.05 (0.24) |
| mI | 4.17 (0.79) | 4.42 (0.78) | 4.55 (0.61) | 4.32 (0.91) |
| Cr | 7.23 (0.59) | 7.60 (1.04) | 7.70 (1.39) | 7.50 (0.61) |
| White matter | 77.80 (0.09) | 76.26 (0.07) | 75.75 (0.06) | 76.72 (0.07) |
| Grey matter | 21.83 (0.08) | 23.42 (0.06) | 23.94 (0.05) | 22.95 (0.07) |
| CSF | 00.37 (0.01) | 00.30 (0.00) | 00.28 (0.00) | 00.31 (0.00) |
Data are presented as mean (SD)
Significant group differences are represented by *P < 0.05
Glu Glutamate, NAA N-acetyl-aspartate, Cr creatine, mI myo-inositol, Cho choline