Table 4.

DEGs and molecular signature related to heme metabolism in S3 dataset

Group	SV	NSV
N° DEGs	584	775
↑/↓	↑231 and ↓353	↑298 and ↓477
FDR	2.66E−08	5.33E−09
Enrichment position	8th of 40	10th of 48
N° Genes	16	19
	↑ AHSP	↑ AHSP
	↑ ALAS2	↑ ALAS2
	↓ AQP3	↓ AQP3
	↑ BPGM	↑ BPGM
	↑ CA1	↑ CA1
	↑ GYPA	↑ GCLM
	↑ GYPB	↑ GYPA
	↑ HBD	↑ GYPB
	↑ ISCA1	↑ HBD
	↑ LRP10	↑ ISCA1
	↑ MBOAT2	↑ LMO2
	↑ NUDT4	↑ LRP10
	↑ RHCE	↑ MBOAT2
	↑ SLC22A4	↑ NUDT4
	↑ SNCA	↑ RHCE
	↑ XK	↑ SLC22A4
		↑ SNCA
		↑ TMCC2
		↑ XK

SVsurviving group, NSVnon-surviving group; ↑ Upregulated genes and ↓ downregulated genes