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. 2019 Aug 1;9:11177. doi: 10.1038/s41598-019-47581-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Epigenetic genes are transcriptionally downregulated in lung fibroblasts (IRM90) by miR-6127, miR-6746-5p, miR-6787-5p, and miR-mix. IRM90 was transfected with miR-6127, miR-6746-5p miR-6787-5p and miR-mix for 24 h (n = 3). (a) The GO-Enrichment analysis from four lists (miR-6127, miR-6746-5p and miR-6787 and miR-mix) of downregulated genes of transfected IMR90 versus untreated. (b) Venn diagram of significantly downregulated transcript lists of miRNA transfections revealed 22 genes in common. (c) GO terms of the common genes show biological processes mainly related to epigenetic genes. GO = Gene Ontology.