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. 2019 Aug 1;9:11191. doi: 10.1038/s41598-019-47665-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of Wnt signaling in the post-migratory CNC reduces snai2 and sox9 expression. A,B. Wild-type embryos were treated with XAV939 (5 μM), IWR1-endo (10 μM) or DMSO from stage ~28 to ~35, and processed for in situ hybridization for snai2 (A) or sox9 (B). (C,D) One blastomere of 2-cell stage embryos was injected with 50 pg of mRNA encoding EnR-LefΔN-GR^755A. Embryos were treated with DEX or DMSO (as control) from stage ~28 to ~35, and processed for in situ hybridization for snai2 (C) or sox9 (D). A representative tadpole from each treatment group is shown in side view in the upper panels (in C,D both the uninjected and injected sides of the same embryos are displayed side by side for comparison), and statistics is shown in the graphs. White arrowheads point to reduced staining in the condensing mesenchyme in the pharyngeal arches. **P < 0.01; ***P < 0.001.