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. 2019 Aug;5(4):a004093. doi: 10.1101/mcs.a004093

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© 2019 Toh et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial License, which permits reuse and redistribution, except for commercial purposes, provided that the original author and source are credited.

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Figure 1. — (A–C) Pedigrees of the cases identified with BARD1 germline mutation: (A) S69 BARD1 c.73G>C, (B) S519 BARD1 c.1833dupT, and (C) S531 BARD1 c.2099delG. (BC) Breast cancer, (CO) colon cancer, (ESO) esophageal cancer, (PanC) pancreatic cancer, (PC) prostate cancer. (D) Distribution of BARD1 germline mutation. Functional domains include the following: RING (residues 26–119), RAD51-binding (residues 123–162), ANK (residues 425–555), and BRCT (residues 566–777). The lolliplots were drawn using St. Jude PeCan Data Portal.